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在药片上停留时间:根据力而定停留时间与几何停留时间的停留时间
1Leading Research Group, Faculty of Pharmacy, Riga Stradiņš University, Riga, Latvia.
Pharmaceutical development and technology
|July 24, 2024
概括
几何停留时间 (GDT) 是一种平板电脑制造参数. 这项研究将GDT与压缩模拟器记录的停留时间 (DTF) 进行了比较,发现DTF取决于压缩力和配方,特别是在较低的压力下.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 停留时间显著影响平板电脑的性能,对于制造规模扩大至关重要.
- 几何停留时间 (GDT) 是从压力几何学中得出的理论值.
- 压缩模拟器记录的停留时间 (DTF) 提供经验数据.
研究的目的:
- 为了将GDT与DTF进行模拟旋转平板印刷机的比较.
- 评估配方成分对DTF的影响.
- 分析压缩力和DTF之间的关系.
主要方法:
- 使用微晶纤维素 (CEOLUSTM UF-711) 和酸 (DI-CAFOS® A60) 混合物制备药片.
- 一个压缩模拟器 (STYL'One Nano) 在70rpm和10-50kN压缩压力下分析了DTF.
- 基于模拟的旋转压力机参数计算了GDT.
主要成果:
- GDT持续为14.4个月.
- DTF因压缩力和特定配方而有所不同.
- 不同配方的DTF值之间的差异在较高的压缩力 (10-15 kN) 中减少.
结论:
- DTF比GDT更准确地表示旋转平板电脑压缩机的停留时间.
- 压缩力和配方成分是影响DTF的关键因素.
- 了解这些因素对于优化平板电脑制造和扩展至关重要.
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