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Updated: Jun 19, 2025

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

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野生型α-Synuclein结构和聚合:一个全面的粗粒度和全原子分子动力学研究.

Gabriel F Martins1, Nuno Galamba1

  • 1BioISI─Biosystems and Integrative Sciences Institute, Faculty of Sciences of the University of Lisbon, C8, Campo Grande, 1749-016 Lisbon, Portugal.

Journal of chemical information and modeling
|July 24, 2024
PubMed
概括

对α-synuclein (α-syn) 的粗粒度模型显示聚合行为的显著差异. 通过特殊的改进,Sirah2模型准确地模拟了与帕金森病药物发现相关的α-syn聚合.

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相关概念视频

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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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