在COVID-19疫苗接种后对肉毒素A的暂时延迟过敏反应:一个病例系列
Fabio Daniel Padilla-Pantoja1, Nabil Fakih-Gomez2, Cristina Muñoz-Gonzalez2
1Department of Ophthalmology, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain.
Aesthetic plastic surgery
|July 24, 2024
概括
接种COVID-19疫苗可能会导致对A型肉毒素 (BTX-A) 注射的暂时延迟过敏反应. 这些反应随着治疗而消失,并在挑测试后不再复发.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 化品科学 化品科学
背景情况:
- 对毒素A型 (BTX-A) 的过敏反应在化品应用中很少见.
- COVID-19疫苗接种对BTX-A治疗的潜在免疫效应尚未得到充分证实.
研究的目的:
- 报告COVID-19疫苗接种后BTX-A的最大的临时延迟过敏反应 (DHR) 病例系列.
- 描述接种疫苗后第一例DHR与肉毒素A (incoBTX-A) 的情况.
主要方法:
- 在COVID-19疫苗接种后经历DHR到BTX-A的12名患者的回顾性多中心病例系列.
- 患者接受了BTX-A用于面部节律;COVID-19 mRNA疫苗接种发生在1-7个月前.
- 在50%的患者中,皮内过敏测试呈阴性.
主要成果:
- 所有12名患者都出现了DHR,在BTX-A注射后24小时内出现了面部胀和红血.
- 10名患者接受了incoBTX-A,另外2名患者接受了纳毒素A (onaBTX-A).
- 临床症状通过全身皮质类固醇和抗组胺药物得到缓解. 一年后的BTX-A挑试验没有显示任何不良影响.
结论:
- 似乎COVID-19疫苗接种与BTX-A的临时DHR有关.
- 在挑测试中没有不良事件表明过渡性免疫效应.
- 临床医生在给BTX-A时应考虑患者的免疫史.
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