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酸胺功能化酸纳米颗粒对牙结合的作用

Tattiana Enrich-Essvein^1,2, Santiago González-López³, Alejandro B Rodríguez-Navarro⁴

¹Department of Operative Dentistry, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Maximo s/n, Granada, E-18071, Spain. tattiana@ugr.es.

Clinical oral investigations

|July 24, 2024

概括

素素功能化酸纳米颗粒 (nHAp_PA) 预处理显著增强牙键强度和降低矩阵金属蛋白酶 (MMP) 活性. 这种保护作用在老化6个月后仍然存在,这表明粘合剂的耐用性有所改善.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
在牙科的纳米技术.

背景情况:

丁丁结合易受内源酶,主要是矩阵金属蛋白酶 (MMP) 的降解.
纳米颗粒有可能提高牙粘合剂的性能和耐用性.
普罗安东基亚尼丁 (PA) 以其MMP抑制特性而闻名.

研究的目的:

为了研究proanthocyanidin-functionalized hydroxyapatite纳米粒子 (nHAp_PA) 作为牙预处理的疗效.
评估nHAp_PA对微拉伸键强度 (μTBS) 和老化后MMP活性的影响.
为了确定nHAp_PA的最佳度,以增强牙结合.

主要方法:

人类牙块被预处理以不同度的nHAp_PA (2%,6.5%,15%) 或对照.
应用了一种自蚀刻粘合剂和树脂复合物,然后进行pH循环和人工老化24小时6个月.
微拉伸键强度 (μTBS) 和内源酶活性 (MMP-2,MMP-9) 通过μTBS,凝压缩图和现场压缩图进行评估.

主要成果:

与对照组相比,所有nHAp_PA度在24小时内显著增加了μTBS,没有度依赖的差异.
人工老化降低了结合强度,但2%的nHAp_PA组在6个月后保持了比对照组显著更高的μTBS.
nHAp_PA预治疗有效降低了MMP-2和MMP-9活性,与衰老6个月后的负对照相比.

结论:

用nHAp_PA对牙进行预处理,可以提高自蚀刻粘合剂的粘合性能.
nHAp_PA有效地抑制牙中的内源性MMP活性,有助于改善结合耐久性.
2%的nHAp_PA度显示出对长期牙结合稳定性的有希望的结果.

关键词:

原的交叉链接器丹丁的生物修饰多元化产业计划 (MMPs) 是指多元化的产业计划.微拉力键的强度是微拉力键的强度.纳米材料是一种纳米材料.怀孕图片怀孕图片怀孕图片

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