在SARS-CoV-2感染后的肌痛性脑筋炎/慢性疲劳综合征
Elizabeth R Unger1, Jin-Mann S Lin1, Lauren E Wisk2
1Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA network open
|July 24, 2024
概括
这项研究发现,在感染后12个月内,有或没有SARS-CoV-2感染的个体之间,肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS) 类似疾病的患病率没有显著差异. 这些发现表明,ME/CFS类疾病与COVID-19没有直接联系.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 在SARS-CoV-2感染后的慢性症状,包括认知问题,类似于肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 的慢性症状.
- 了解SARS-CoV-2和ME/CFS类疾病之间的潜在联系对于公共卫生和患者护理至关重要.
研究的目的:
- 为了确定SARS-CoV-2感染后的ME/CFS类疾病的患病率.
- 在12个月内追踪ME/CFS症状的变化.
- 调查ME/CFS症状与SARS-CoV-2感染状态之间的关联.
主要方法:
- 一项前性的多站点纵向队列研究 (INSPIRE注册表) 招募了18-64岁的急性SARS-CoV-2暗示性疾病的成年人.
- 参与者在入学时接受了SARS-CoV-2的测试,并通过调查进行了长达12个月的跟踪.
- 使用2015年医学院标准,根据自我报告的症状来评估ME/CFS类疾病.
主要成果:
- ME/CFS类疾病的患病率在疾病发病后3至12个月保持稳定.
- 在COVID-19阳性 (2.8%-3.7%) 和COVID-19阴性 (3.1%-4.5%) 组中,患病率相似.
- 在COVID-19阳性和阴性个体之间没有发现ME/CFS类疾病几率的显著差异.
结论:
- 这项研究没有发现证据表明SARS-CoV-2感染增加了患ME/CFS类疾病的风险.
- 持续3%-4%的ME/CFS类疾病患病率表明,不管SARS-CoV-2的状况如何,这意味着一个重大的社会负担.
- 需要进一步的研究来了解ME/CFS类疾病的潜在机制和管理.
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