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Updated: Jun 19, 2025

Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

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Published on: October 5, 2012

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通过两步机制,BclxL通过BclxL优先抑制亲细胞灭绝的Bak

Kira D Leitl1, Laura E Sperl2, Franz Hagn1

  • 1Bavarian NMR Center (BNMRZ), Department of Bioscience, School of Natural Sciences, Technical University of Munich, 85747 Garching, Germany; Molecular Targets and Therapeutics Center (MTTC), Institute of Structural Biology, Helmholtz Munich, 85764 Neuherberg, Germany.

Cell reports
|July 24, 2024
PubMed
概括

研究人员发现了Bcl-2-like蛋白1 (BclxL) 的第二个结合部位Bakα1,这解释了BclxL如何抑制Bak介导的亡. 这一发现澄清了在编程细胞死亡过程中Bcl2蛋白家族相互作用的机制.

关键词:
CP: 细胞生物学 细胞生物学科普:分子生物学 分子生物学在HDX-MS中使用HDX-MS.这是NMR的NMR.灭症 (apoptosis) 是一种死亡的过程.抑制抑制抑制的抑制作用脂质纳米光盘的使用膜膜膜膜是一种

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