饮食和饮水限制导致对抗微生物耐药性病原体的敏感性增加
Keenan A Lacey1, Adam M Pickrum2, Sandra Gonzalez1
1Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
饮食和饮水限制 (DWR) 显著增加了患者对细菌感染的敏感性. 这种限制会损害免疫细胞的功能,导致多抗药性病原体的死亡率和发病率更高.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 脱水和营养不良在医院中很普遍,经常被忽视.
- 耐多药性细菌感染导致医院患者的大量死亡率.
研究的目的:
- 调查临时饮食和饮水限制 (DWR) 对对多药耐药病原体的敏感性的影响.
- 阐明DWR影响宿主防御细菌感染的机制.
主要方法:
- 使用了一种对甲基西林耐药黄金葡萄球菌感染的小鼠血流模型.
- 进行了死亡率,发病率,细菌负担,病理和细胞功能 (巨细胞) 的评估.
主要成果:
- 在感染S.的小鼠中,DWR显著增加了死亡率和发病率. 黄金色. 黄金色
- 严重的DWR导致细菌负担增加和严重的病理,细胞功能发生改变.
- 在DWR条件下观察到细菌的巨细胞和中性粒细胞的细胞受损.
结论:
- 暂时的饮食和饮水限制会损害免疫系统对抗细菌感染的能力.
- 保持足够的水分和营养对于预防多药耐药病原体的严重后果至关重要.
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