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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Updated: Jul 13, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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复发性转移性免疫疗法响应性小纤维神经病变:长度追踪10年,包括怀孕.

Anne Louise Oaklander1, Julia Allen1, Nadja Dietliker1

  • 1From the Department of Neurology (A.L.O.), Massachusetts General Hospital and Harvard Medical School; Department of Pathology (Neuropathology) (A.L.O.), Massachusetts General Hospital; Harvard T.H. Chan School of Public Health & Harvard Medical School (J.A.), Boston; Department of Medical Oncology and Hematology (N.D.), University Hospital Zurich; Department of Neurology (E.P.W.-S.), University of Bern; and Department Neruology (Neurozentrum) (E.P.W.-S.), Luzerner Kantonsspital, Switzerland.

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PubMed
概括

这项研究跟踪了一名患有小纤维多神经病变 (SFN) 的女性超过五年,揭示了复发缓解的过程. 多种免疫疗法是有效的,即使在怀孕和母乳养期间.

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科学领域:

  • 神经学 神经学
  • 免疫学 免疫学 免疫学

背景情况:

  • 小纤维多神经病变 (SFN) 是一种影响小神经纤维的疾病,通常原因不明.
  • 了解SFN的长期过程和治疗反应对于患者管理至关重要.

研究的目的:

  • 为了研究病变发生,临床表现和治疗疗效,在初始异常性SFN的情况下.
  • 描述疾病的过程和长期对各种免疫疗法的反应.

主要方法:

  • 通过使用验证的指标长度监测了一名经活检确认的异常性SFN患者.
  • 疾病的发展过程和对治疗的反应,包括普雷尼松,免疫球蛋白,利图西马布,达拉图穆马布,贝利穆马布和等离子体酶,在五年内被跟踪.

主要成果:

  • 病毒感染引发了手,脚和脸部的红色肌痛 (灼热疼痛) 的反复发作.
  • 患者经历了复发缓解的过程,发作对不同的免疫疗法有反应,包括怀孕期间和产后.
  • 通过多次治疗,成功实现了管理,使得怀孕健康,并在母乳养期间持续缓解.

结论:

  • 观察到的复发复发模式和对多种免疫疗法的反应表明,这种SFN病例的免疫不良病因.
  • 经过验证的指标对定义疾病过程和评估治疗有效性起了重要作用,特别是在像怀孕这样的复杂情景中.