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在双边已故捐赠者肺移植后的基线肺全移植功能障碍:在日本的一个单一中心的经验

Miho Yamaguchi¹, Mitsuaki Kawashima², Tatsuya Muraoka²

¹Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan; Department of Respiratory Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Respiratory investigation

|July 24, 2024

概括

日本肺移植接受者的基线肺异位功能障碍 (BLAD) 与其他人群相似. BLAD与更长的ICU停留和呼吸器持续时间有关,但与生存无关.

科学领域:

肺部医学肺部医学
移植手术移植手术
关键的护理关键的护理

背景情况:

基线肺异位移植功能障碍 (BLAD) 的特征是肺功能<80%预测的肺移植后.
BLAD与更糟糕的预后有关,但在日本人口中缺乏数据.

研究的目的:

调查日本肺移植接受者的BLAD的特征和结果.
将BLAD患者与非BLAD患者进行比较.

主要方法:

对经过双边肺移植的38名日本成年人 (2015-2022) 的回顾性分析.
接受者和供体因子,术后变量和BLAD和非BLAD组之间的生存率的比较.

主要成果:

55%的患者表现出BLAD.
BLAD组预测的生命能力比率较低 (p=0.009),ICU停留时间增加,呼吸器持续时间和血液损失.
没有观察到生存时间的显著差异.
在BLAD组中,中位观察期较短 (744天对1192天,p=0.031).

结论:

日本患有BLAD的患者与国际队列具有相似的特征.
需要进一步研究观察时间和捐赠者-接受者年龄不匹配对BLAD的影响.

关键词:

基线肺异位移植功能障碍肺异位移植功能障碍在1秒内强制呼气体积.强迫生命能力强迫生命能力.肺移植肺移植肺移植肺功能肺功能肺功能

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