孕前暴露于甲酸盐的健康危害:流行病学研究的范围审查
Li-Wen Chen1, Hua-Yan Mo1, Chun-Han Shan1
1Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China.
Ecotoxicology and environmental safety
|July 24, 2024
概括
在受孕前,父母暴露于酸 (PAE) 可能会影响生殖结果和后代的健康,影响出生体重和行为. 需要更多的研究来证实这些影响,并为公共卫生政策提供信息.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 发育儿科 发育儿科
背景情况:
- 怀孕前的健康显著影响着跨世代的母亲和孩子的福祉.
- 在怀孕前期暴露于酸 (PAE) 可能会扰乱子体生殖和表观遗传编程.
- 新出现的证据将父母PAE暴露与不良的生殖和发育结果联系起来.
研究的目的:
- 审查父母的孕前甲酸 (PAE) 暴露对生殖/分娩结果和后代健康的影响.
- 综合目前关于PAE暴露对生育,怀孕和儿童发育的影响的证据.
- 确定研究缺口,并为公共卫生战略提供有关怀孕前环境暴露的信息.
主要方法:
- 在主要的科学数据库 (Web of Science,PubMed,CNKI,ScienceDirect,VIP Journal Library) 进行系统的文献搜索,截至2024年7月3日.
- 包括12项研究,检查与生殖健康和后代结果有关的PAE暴露.
- 研究的分类基于暴露 (仅母体,双亲) 和结果 (生殖/分娩,后代行为) 的结果.
主要成果:
- 父母的预见PAE暴露与对生殖/分娩结果的影响有关,包括出生体重,怀孕流产和早产.
- 九项研究调查了对生殖/分娩结果的影响,重点关注出生体重,胚胎和胎盘体重.
- 三项研究探讨了孕前PAE暴露对后代行为的影响,包括一般和饮食行为.
结论:
- 父母的偏见PAE暴露对生殖健康和后代发育构成潜在风险,影响出生体重和行为.
- 目前关于孕前PAE暴露对健康的危害的研究是有限的,结果各不相同.
- 进一步的系统审查和有针对性的研究对于确定最终结论和指导公共卫生政策至关重要.
更多相关视频
06:46Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
Published on: June 2, 2023
1.7K
08:28Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
Published on: April 26, 2018
5.9K
相关概念视频
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
