肠道微生物组模型预测了在直肠癌中对新辅助免疫疗法加上化学放射治疗的反应
Zhengyang Yang1, Jingxin Ma2, Jiagang Han3
1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases, Beijing, China.
Med (New York, N.Y.)
|July 24, 2024
概括
一个新的模型准确地预测了接受新辅助免疫疗法加化学放射治疗 (nICRT) 的局部晚期直肠癌患者的治疗反应. 这种个性化的方法有助于临床医生根据肠道微生物组量身定制治疗,改善结果.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 个性化医疗是个性化的医疗.
背景情况:
- 评估局部晚期直肠癌 (LARC) 治疗反应具有挑战性,特别是在新辅助免疫疗法加化学辐射疗法 (nICRT) 时.
- 个性化治疗计划对于优化LARC患者的治疗结果至关重要.
研究的目的:
- 在LARC患者的nICRT期间评估动态肠道微生物群变异.
- 开发和验证对nICRT的病理完整反应 (pCR) 的预测模型.
主要方法:
- 一项前性多中心队列研究,涉及用nICRT治疗的LARC患者.
- 分析肠道微生物组合和整个nICRT的动态变化.
- 开发和验证物种级肠道微生物组预测 (SPEED) 模型.
主要成果:
- 该研究在接受nICRT的LARC患者中观察到42.4%的pCR率.
- 基线时明显的肠道微生物组概况与治疗反应有关.
- 该SPEED模型在预测pCR方面表现出高准确性,AUC为98.80% (培训) 和77.78% (验证).
结论:
- 新辅助剂PD-1阻断加CRT耐受性良好,在特定的LARC患者群体中显示出有利的pCR率.
- 使用基线肠道微生物组数据的SPEED模型提供了一种可靠和准确的方法来预测nICRT反应.
- 这种预测能力可以帮助临床医生为LARC患者制定个性化管理策略.
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