针对TRPV1信号传递:Galangin改善了乙醇诱导的胃粘膜损伤
Kaiwen Lin1, Zhongtao Wang1, Erhao Wang1
1Hainan Women and Children's Medical Center, Haikou, 570312, China.
Journal of ethnopharmacology
|July 24, 2024
概括
甘拉丁通过抑制TRPV1通路,有效地防止酒精诱导的胃损伤. 这种天然化合物对治疗胃粘膜损伤有前途.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 胃肠病学 胃肠病学
- 自然产品化学 自然产品化学
背景情况:
- 甘,来源于Alpinia officinarum,具有用于胃肠道疾病的历史性民族药理学用途.
- 虽然加拉显示出胃的潜力,但其精确的分子抗机制仍然不清楚.
研究的目的:
- 在小鼠中研究加拉对乙醇诱导的急性胃粘膜损伤 (AGMI) 的保护作用.
- 为了阐明参与加拉抗活动的分子途径.
主要方法:
- 建立了一个AGMI小鼠模型,并用galangin,omeprazole或capsazepine进行治疗.
- 评估了粘膜损伤,炎症 (IL-1β,IL-6,IL-8,TNF-α),氧化应激 (SOD,MDA) 和MMP活性.
- 通过分子对接评估了galangin与TRPV1通路蛋白的结合亲和力,并分析了关键蛋白/mRNA表达 (TRPV1,NGF,TRKA,TGF-β,COX-2,NF-κB,BCL-2,BAX,Caspase-3).
- 在胃上皮细胞 (GES-1) 中研究了细胞增殖,细胞亡,迁移,细胞内和线粒体膜潜力的影响.
主要成果:
- 甘巴林显著降低了胃指数和炎症,同时改善了抗氧化剂状态 (增加SOD,减少MDA).
- 它抑制了MMP-2和MMP-9,促进了粘膜的修复,并使胃细胞中的细胞内和线粒体潜能正常化.
- 甘达林对TRPV1和相关蛋白质进行了结合,降低了它们的表达和相关的炎症/亡标志物,同时上调了Bcl-2等保护因素.
结论:
- 甘巴林通过抑制TRPV1通路过度激活和异常信号传导来减轻AGMI.
- 甘拉丁对酒精诱导的胃粘膜损伤具有治疗潜力,提供一种天然的替代治疗方法.
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