行为神经科学中的雌性动物:对方法学的陷进行叙述性审查
Marcela Becegato1, Regina H Silva2
1Behavioral Neuroscience Laboratory, Department of Pharmacology, Federal University of São Paulo, São Paulo, Brazil.
Physiology & behavior
|July 24, 2024
概括
尽管政策发生了变化,但研究人员往往忽视了在临床前研究中充分纳入雌性动物. 本综述强调了方法上的挑战,并提供了在行为神经科学研究中更好地纳入女性受试者的指导方针.
科学领域:
- 行为神经科学 行为神经科学
- 临床前研究 临床前研究
- 动物模型 动物模型
背景情况:
- 美国国家卫生研究院的"性别作为生物变量"政策要求增加女性受试者的纳入.
- 尽管政策发生了变化,但许多研究在研究方案中不充分纳入雌性动物.
- 现有的研究往往忽略了性别特异性的生物差异.
研究的目的:
- 审查包括雌性动物在行为神经科学研究中的方法陷.
- 确定与雌性周期监测,卵巢切除和雌性动物激素替代相关的挑战.
- 解决将男性视为标准以及结果解释和出版方面的偏见.
主要方法:
- 对现有的关于女性动物被纳入行为神经科学的文献进行叙述性审查.
- 分析常见的方法挑战和偏见.
- 制定改善女性受试者包容性的指导方针.
主要成果:
- 在雌性动物中,需要仔细考虑特定的操作 (例如,期周期监测).
- 使用男性作为标准的倾向可以引入偏见.
- 出版和解释偏见可能会进一步扭曲女性受试者的结果.
- 缺乏针对雌性动物的标准化方案,阻碍了研究进展.
结论:
- 解决方法上的陷对于涉及雌性动物的准确临床前研究至关重要.
- 需要标准化的指导方针,以确保公平和强大的女性受试者的纳入.
- 改进的方法将提高行为神经科学发现的有效性和通用性.
相关概念视频
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