巨型综合体保护ER-alpha免受Fulvestrant在上皮卵巢癌中的降解

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Sushil Kumar Jaiswal1, Kevin Fedkenheuer1, Ronak Khamar1

  • 1Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA.

Cancer letters
|July 24, 2024
PubMed
概括

由于核雌激素受体α (ERα) 在蛋白质复合体内,卵巢癌细胞对Fulvestrant (ICI) 具有抗性. 将ICI与JQ1药物结合起来可以克服这种抗药性,提供一种新的治疗策略.

关键词:
这是一种BRD4抑制剂.在 ChIP-seqq.药物耐药性 药物耐药性 药物耐药性雌激素受体的受体是什么凝过的过方法在 ICI182780 找 ICI182780JQ1 一个问题这是一个巨型综合体.卵巢癌是发生在卵巢中的癌症.这是一个超级增强器.

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