与癌症相关的内分泌细胞参与胰腺癌发生
Yuan Chen1, Xinpeng Yin1, Ruiyuan Xu1
1Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Gastroenterology
|July 24, 2024
概括
在胰腺管腺癌 (PDAC) 的发展过程中,胰腺内分泌细胞发生变化. PDAC细胞诱导内分泌细胞转分化,通过相互的内分泌-外分泌相互作用促进癌症生长.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 胰腺具有不同的内分泌和外分泌功能,具有潜在的细胞相互作用.
- 胰腺管道腺癌 (PDAC) 瘤微环境是已知的,但内分泌细胞在致癌过程中的作用还未得到充分研究.
研究的目的:
- 将PDAC中的内分泌细胞变化映射到地图上.
- 阐明PDAC致癌过程中的内分泌外分泌相互作用机制.
主要方法:
- 单细胞和空间转录基因组测序.
- 多重复合免疫组织化学.
- 在体内和体外模型,包括正位体移植和共同培养实验.
主要成果:
- 胰腺内分泌细胞表现出改变的转录形状和与PDAC内外分泌区的相互作用增加.
- 胰腺多阳性细胞随着癌症的进展而增加,可能来自α和β细胞转分.
- PDAC细胞诱导α和β细胞转分为双阳性细胞,通过膜信号传递促进PDAC.
结论:
- 这项研究系统地描述了PDAC中的内分泌细胞变化.
- 阐明了PDAC致癌的内分泌外分泌相互作用的潜在机制.
- 定义了与癌症相关的内分泌细胞,扩大了对PDAC微环境的理解.
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