来自Evolut低风险TAVR双虫研究的3年结果
Firas Zahr1, Basel Ramlawi2, Michael J Reardon3
1Oregon Health & Science University, Portland, Oregon, USA.
JACC. Cardiovascular interventions
|July 24, 2024
概括
在患有双主动脉狭窄症的低风险患者中,透气管大动脉置换 (TAVR) 显示了有利的3年后的结果. 进化低风险双虫研究发现死亡率和中风率较低,没有中度或重度的膜大动脉吐.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 有限的数据存在于通过导管的大动脉置换 (TAVR) 的结果超过两年在低手术风险的双大动脉狭窄的患者.
- 双主动脉解剖学对TAVR手术提出了独特的挑战.
研究的目的:
- 为了评估TAVR使用Evolut自扩展生物假体的3年临床和心声结果,在患有低手术风险和双主动脉狭窄症的患者中.
- 评估TAVR在这个特定患者群体中的安全性和有效性.
主要方法:
- 展望型,多中心,单臂研究 (Evolut低风险双子研究) 涉及150名低风险患者,患有严重的大动脉狭窄和双子大动脉解剖.
- 患者接受了一种自我扩张的,超状的Evolut R或PRO生物假体.
- 临床事件和心声回声数据被独立判断和评估.
主要成果:
- 全因死亡率或致残性中风的3年卡普兰-梅尔率为4.1%.
- 在TAVR后的2或3年内,没有观察到中度或严重的偏门大动脉吐.
- 在3年后,新的永久心脏起器植入的发生率为19.4%.
结论:
- 进化低风险双管研究表明,在患有双管大动脉狭窄症的低风险患者中,TAVR的3年临床结果是有利的.
- 这些发现支持在这个人群中使用这种TAVR设备,显示低死亡率/中风率和良好的血液动力学性能.
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