常规的母体ABO/Rhesus D血型测试可以提醒巨大的胎儿母体出血
Lilach Bonstein1,2, Hussaien Khaldi1, Eldad J Dann1,2
1Blood Bank and Platelet Immunology Laboratories, Haifa, Israel.
Vox sanguinis
|July 24, 2024
概括
在母体血型鉴定中检测混合场红细胞凝结可以帮助诊断自发性巨大的胎儿母体出血 (SM-FMH). 这一发现有助于识别一种罕见但危急的疾病,可能挽救胎儿的生命.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 新生儿科学 新生儿科学
背景情况:
- 自发性巨大的胎儿母亲出血 (SM-FMH) 是一种罕见的产科紧急情况,对胎儿健康有重大风险.
- 许多SM-FMH病例可能没有被诊断出来,这凸显了改善诊断方法的必要性.
研究的目的:
- 调查和验证混合场红细胞 (RBC) 凝结在母体血型鉴定中的使用,作为SM-FMH的诊断辅助.
- 评估混合场聚合和SM-FMH确诊病例之间的相关性.
主要方法:
- 追溯分析2016年至2023年间出生的新生儿的医疗记录.
- 诊断SM-FMH基于新生儿严重贫血 (血红素值<15%) 在分娩后24小时内,以及母亲的Kleihauer-Betke测试阳性.
- 对母亲的ABO/Rhesus D (RhD) 血型检测结果进行审查,以证实双重红细胞群的存在.
主要成果:
- 在29,192名新生儿中,5例 (0.02%) 被诊断为严重的SM-FMH.
- 在80%的SM-FMH病例中 (5例中4例) 观察到混合场红细胞凝结.
结论:
- 在产前产妇血型鉴定期间混合场红细胞凝结是SM-FMH的重要潜在指标.
- 提高医疗保健专业人员对这种实验室发现的认识,可以帮助早期诊断和干预.
- 通过血型鉴定快速识别SM-FMH可以有助于改善胎儿的结果.
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