在肝硬化相关并发症中,肠道微生物组和代谢组特征
Satya Priya Sharma1, Haripriya Gupta1, Goo-Hyun Kwon1
1Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Korea.
Clinical and molecular hepatology
|July 24, 2024
概括
肠道微生物群和代谢物表现出与肝硬化及其并发症相关的独特特征. 这些发现为诊断肝硬化和相关疾病提供了潜在的非侵入性生物标志物.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群和代谢物变化与肝硬化进展和并发症有关.
- 这些变化与肝硬化结果之间的因果关系需要全面评估.
研究的目的:
- 为了识别肠道微生物群和特定于肝硬化的代谢特征.
- 在肝硬化患者中调查依赖并发症的微生物和代谢概况.
主要方法:
- 194个便样本的16S rRNA测序 (142名肝硬化患者,52名对照).
- 在51个样本上使用GC-MS和LC-MS/MS进行便代谢物分析.
- 对微生物群,代谢物,临床参数和并发症的相关性分析.
主要成果:
- 特定的细菌 (例如,Veillonella,Ruminococcus gnavus) 与肝硬化有关.
- 显著的微生物特征与肝硬化并发症有关.
- 五种便代谢物被确定为肝硬化和并发症的生物标志物 (AUROC>0.880).
- 微生物群和代谢物与临床标志物显著相关.
结论:
- 肝硬化有明显的肠道微生物群和代谢物概况的特征.
- 这些签名作为潜在的非侵入性生物标志物用于诊断肝硬化及其并发症.
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