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美国成年人的金属植入物和尿水平之间的关联:NHANES的横截面研究
Xiaogang Qi1, Jiaming Liu2, Wenhai Liu3
1Department of Orthopedics, Yangquan First People's Hospital, Yangquan, 045000, China.
Scientific reports
|July 24, 2024
概括
金属植入物与更高的尿 (Cr) 水平有关,特别是在女性身上. 这种联系随着年龄的增长而增强,突出了骨科植入物对健康的潜在影响.
科学领域:
- 整形外科手术 整形外科手术
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 金属植入物在骨科手术中被广泛使用.
- (Cr) 是许多骨科植入物的组成部分.
- 金属植入物对尿液Cr水平的影响尚不清楚.
研究的目的:
- 调查金属植入物存在与尿中Cr水平之间的关联.
- 探索这种关系中的潜在的性别特异性差异.
- 检查具有或没有金属植入物的个人尿液Cr水平的年龄的影响.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2017-2020) 进行的横截面研究.
- 包括1419名40岁及以上的参与者.
- 多变量线性回归和子组分析以评估相关性.
主要成果:
- 在对混杂因素进行调整后,发现金属植入物和尿液Cr水平 (β=0.41,p=0.028) 之间存在正相关性.
- 这种相关性在女性中显著 (β=0.81,p=0.029),但在男性中没有显著.
- 与没有植入物的人相比,植入物的人与年龄相比,尿液Cr的增加更为明显.
结论:
- 金属植入物的存在与尿中含量升高有关.
- 存在性别特异性差异,女性表现出更强的关联.
- 年龄是一个重要因素,老年人与植入物呈现较高的尿 Cr.
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