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Updated: Jun 19, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

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通过设计选择性治疗耐药性来增强癌症中的细胞免疫疗法

Nils Wellhausen1, Joanne Baek1, Saar I Gill2,3,4

  • 1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nature reviews. Cancer
|July 24, 2024
PubMed
概括

工程细胞疗法,如CAR-T细胞,在癌症缓解方面表现有前途. 探讨了改善其持久性,安全性和组合潜力的策略,克服目前的局限性,以获得更广泛的患者利益.

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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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