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Updated: Jun 19, 2025

Primary Microglia Isolation from Mixed Glial Cell Cultures of Neonatal Rat Brain Tissue
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在发育过程中微线粒体复合体I缺乏导致质功能障碍和早期死亡.

Bella Mora-Romero1,2,3, Nicolas Capelo-Carrasco1,3,4, Juan J Pérez-Moreno5,6,7

  • 1Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.

Nature metabolism
|July 24, 2024
PubMed
概括

微质中的线粒体缺陷有助于原发性线粒体疾病 (PMD). 这些大脑免疫细胞中受损的复合体I会导致功能障碍和神经症状,这表明PMDs是一个新的治疗点.

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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