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Updated: Jun 19, 2025

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微质中的线粒体呼吸对于对脱髓化损伤的反应至关重要,但不是扩散

Joshua S Stoolman1, Rogan A Grant2, Taylor A Poor2

  • 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. joshua.stoolman@northwestern.edu.

Nature metabolism
|July 24, 2024
PubMed
概括

线粒体呼吸对于微质细胞的生存或增殖并不是必不可少的. 然而,微质中的线粒体功能受损阻碍了中枢神经系统修复脱髓化损伤的能力.

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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