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Updated: Oct 29, 2025

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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一个人类自身免疫器官模型揭示了胆固醇疾病中的IL-7功能

António J M Santos1, Vincent van Unen1,2,3, Zhongqi Lin1

  • 1Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|July 24, 2024
PubMed
概括

研究人员开发了先进的十二指肠器官,以模拟谷病 (CeD),一种由质诱导的自身免疫疾病. 这些器官成功地复制了依赖质的免疫反应和上皮损伤,为CeD的发病提供了新的见解.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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