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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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新抗原特异性细胞毒性Tr1 CD4 T细胞抑制癌症免疫疗法

Hussein Sultan1,2, Yoshiko Takeuchi1,2, Jeffrey P Ward3

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Nature
|July 24, 2024
PubMed
概括

高剂量的MHC- II新抗原疫苗诱导细胞毒性1型调节T (Tr1) 细胞,通过杀死树突细胞来抑制抗瘤免疫力. 阻止这种抑制的策略提供了潜在的癌症治疗方法.

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