切除性胃癌患者的生存结果,这些患者接受了全新辅助疗法治疗
Yun Song1, Yuki Hirata2, Jaffer A Ajani3
1Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Annals of surgical oncology
|July 24, 2024
概括
总的新辅助疗法 (TNT) 在局部晚期胃癌患者中显示出有希望的生存率. 较高的治疗完成率和病理完整反应与改善的整体和疾病特异性生存率相关.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 术后化学疗法是局部晚期胃癌的标准.
- 总的新辅助疗法 (TNT) 用于其他胃肠道癌症.
- 这项研究评估了用TNT治疗的胃癌患者的生存结果.
研究的目的:
- 确定用全新辅助疗法 (TNT) 治疗的胃癌患者的生存结果.
- 评估接受TNT的患者的治疗完成率和预后因素.
主要方法:
- 一个潜在的机构数据库确定了203名胃腺癌患者 (cT2-4或cN+),他们在2012年1月至2022年6月期间接受了TNT治疗.
- 生存分析包括整体生存率 (OS) 和疾病特异性生存率 (DSS).
- 所有确诊的患者都进行了分期腹腔镜,TNT和胃切除术.
主要成果:
- 最常见的TNT序列是诱导化疗,其次是化学辐射 (91.6%).
- 治疗完成率很高 (96.1%),其中15.8%实现了病理完整反应 (pCR).
- 五年的OS为65.2%,而5年的DSS为70.8%. 患有pCR的患者的生存率明显改善 (5年OS 89.1%,DSS 96.9%). 治疗后的N和M阶段是强有力的预后指标.
结论:
- 可切除胃癌的全新辅助疗法 (TNT) 显示了高治疗完成率和有利的生存率.
- 需要进一步的前性研究来比较TNT与外科手术期间的治疗,并确定最佳候选患者.
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