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自从鸟类的起源以来,独特的肌球蛋白适应内热和飞行
Shengjing Song1, Heye Chen1, Yu Zhang1
1College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi, China.
Integrative zoology
|July 24, 2024
概括
球蛋白在鸟类和蝙蝠中演变的不同. 鸟类发展出更高的净表面电荷,可能是为了适应飞行,而蝙蝠则表现出强烈的净化选择,这表明这种氧结合蛋白的进化路径不同.
科学领域:
- 进化生物学是进化的生物学.
- 分子进化的分子进化.
- 生物化学 生物化学
背景情况:
- 肌球蛋白 (Mb) 对于肌肉中的氧气运输和储存至关重要,支持高有氧代谢.
- 鸟类和蝙蝠独立进化飞行,需要高效的能源利用.
- 在这些飞行群体中,肌球蛋白的功能演变仍然在很大程度上未被探索.
研究的目的:
- 为了重建祖先的肌球蛋白序列,并分析胚胎进化过程中的功能性质.
- 为了研究鸟类和蝙蝠中肌球蛋白的进化适应.
- 了解飞行适应物种中分离的神经蛋白功能的分子基础.
主要方法:
- 来自200多种羊卵物种的肌球蛋白编码序列的遗传学分析.
- 重建祖先的肌球蛋白序列.
- 功能性质的估计,包括净表面电荷和蛋白质稳定性.
主要成果:
- 在鸟类的起源期间,由于积极选择,肌球蛋白净表面电荷的显著增加发生了.
- 蝙蝠肌球蛋白基因表现出强烈的净化选择,净表面电荷没有显著变化.
- 鸟类的肌球蛋白显示较低的稳定性比其他羊动物,可能提高氧气利用,而蝙蝠肌球蛋白更稳定.
结论:
- 鸟类和蝙蝠中肌球蛋白适应的不同进化途径.
- 鸟类肌球蛋白的净表面电荷增加可能是对高体温和飞行需求的适应.
- 蝙蝠和哺乳动物中增强的肌球蛋白稳定性代表了对内热的替代适应.
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