针对肌肉侵入性膀癌的八代人新辅助化疗后的病理反应和生存结果:一个观察数据库研究
Arjun Pon Avudaiappan1, Pushan Prabhakar2, Mayer Simcha Sandman3
1Department of Urologic Oncology Surgery, Miami Cancer Institute, 8900 N Kendall Drive, Miami, FL, 33176, USA. Arjun.PonAvudaiappan@baptisthealth.net.
BMC urology
|July 25, 2024
概括
在激进囊切除术 (RC) 之前的新辅助化疗 (NAC) 改善了肌肉侵入性膀癌 (MIBC) 的八代人生存率. 与非响应者相比,NAC的响应者显示出明显更好的整体存活率 (OS).
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 老年医学 老年医学
背景情况:
- 新辅助化疗 (NAC) 随后的激进囊切除术 (RC) 是肌肉侵入性膀癌 (MIBC) 的标准.
- 八代人越来越多地接受RC,但这个年龄组的NAC利用率较低.
- 关于NAC对八十岁MIBC患者的生存结果的影响的数据有限.
研究的目的:
- 评估使用和存活结果的NAC与RC在MIBC的八十岁.
- 为了比较接受NAC和不接受NAC的八十岁人之间的整体生存率 (OS).
- 为了比较NAC的响应者和非响应者之间的操作系统.
主要方法:
- 国家癌症数据库 (NCDB) (2004-2018) 的回顾性分析.
- 识别了MIBC和泌尿器组织学经过RC或没有NAC的八十岁.
- 倾向匹配分析比较NAC和非NAC队列之间的OS,以及NAC响应者和非响应者之间的OS,不包括并发症指数>1的患者.
主要成果:
- 3056名MIBC的八十岁生符合选择标准;396人获得了NAC.
- 在倾向匹配后,NAC队列的中位数OS为51.6个月,非NAC队列为31.3个月 (p<0.001).
- 对NAC的响应者比非响应者 (26.5个月) 有明显更好的中位数 (89.4个月) (p<0.0001).
结论:
- 与RC结合的NAC可以改善MIBC的健康八十岁人群的生存状况.
- 与非响应者相比,NAC响应者表现出更高的生存结果.
- 结果支持在选择的八十岁的MIBC患者中考虑NAC.
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