探索生物标志物用于诊断和预测患有术后败血症的患者的器官功能障碍:初步调查
Linghui Jiang1, Shiyu Chen1, Shichao Li1
1Department of Anaesthesiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Perioperative medicine (London, England)
|July 25, 2024
概括
新型生物标志物,包括Cathepsin B (CatB) 和S100-A9,显示出早期诊断和预测败血症患者器官功能障碍的希望. 这些标志物可以提高确定手术前败血性功能障碍的准确性.
科学领域:
- 生物化学 生物化学
- 蛋白质组学是指蛋白质组学.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 早期诊断和预测器官功能障碍对于改善败血症患者的结果至关重要.
- 术后败血症在识别有器官功能障碍风险的患者方面存在重大挑战.
- 为了及时干预和管理,需要新的生物标志物.
研究的目的:
- 为了确定器官功能障碍的新型诊断和预测生物标志物在周围手术性败血症患者.
- 评估特定血清蛋白质作为毒引起的器官功能障碍指标的潜力.
- 评估这些生物标志物在术前诊断和术后预测中的有用性.
主要方法:
- 一项前性,受控的,初步的,单中心研究,涉及紧急手术患者.
- 质谱测量以确定败血症患者的差异表达蛋白 (DEP).
- 基因本体学 (GO) 分析,蛋白质与蛋白质相互作用 (PPI) 网络,以及ELISA用于验证和相关性分析.
主要成果:
- 已发现146个DEP;六个被选中进行验证:甲素B (CatB),VCAM-1,NGAL,S100-A9,前素和血素-1.
- 与对照组相比,在败血症患者中观察到这六种蛋白质的水平升高 (p < 0.001).
- CatB,S100-A9,VCAM-1,prosaposin和NGAL显示出诊断器官功能障碍的潜力;CatB和S100-A9预测了功能衰竭.
结论:
- 血清CatB,S100-A9,VCAM-1,prosaposin和NGAL可能成为诊断败血症患者器官功能障碍的新生物标志物.
- S100-A9和CatB特别表明在败血症中出现了手术前的功能障碍.
- 结合S100-A9和CatB可能会提高预测败血性功能障碍的准确性.
相关概念视频
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