多胎妊娠中母亲血红蛋白下降与出生时更高的妊娠年龄和出生体重有关
Kristin Townsend1, Tanya Maric2, Philip J Steer3
1Faculty of Medicine, Imperial College London, London, UK.
Acta obstetricia et gynecologica Scandinavica
|July 25, 2024
概括
在双胞胎怀孕中,在第一和第二个三个月之间,母体血红蛋白 (Hb) 的较大下降与出生时妊娠年龄的增加和出生体重 (BW) 的增加有关. 这一发现可能表明怀孕期间血体积膨胀较大.
科学领域:
- 围产儿医学 围产儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产科 产科 产科 产科 产科
背景情况:
- 双胞胎怀孕带来了独特的生理挑战.
- 孕妇的血红蛋白 (Hb) 水平在怀孕期间通常会发生变化.
- 双胞胎的Hb变化和怀孕结果之间的关系需要进一步研究.
研究的目的:
- 为了测试母亲Hb水平在双胞胎怀孕的第一和第二个三个月之间下降的假设.
- 为了确定更大的Hb下降是否与改善的围产期结果有关,包括出生时的妊娠年龄和出生体重 (BW).
主要方法:
- 对923例双胞胎怀孕的回顾性分析.
- 产妇的Hb和平均体积 (MCV) 记录在第一和第二个三个月.
- 血下降计算为Hb1减去Hb2 (根据妊娠年龄进行调整).
- Hb下降和MCV与出生时妊娠年龄,BW和妊娠年龄小 (SGA) 新生儿的关联.
主要成果:
- 较大的Hb下降与出生时更高的妊娠年龄显著相关 (p < 0.001).
- 双胞胎的Hb下降增加与更大的BW相关 (p < 0.001).
- 较大的Hb下降与SGA新生儿发病率降低有关 (p < 0.001).
- MCV值与这些结果没有显著的相关性.
结论:
- 从第一到第二个三个月的母亲Hb下降较大,在双胞胎怀孕中是一个积极的指标.
- 这种Hb下降与更好的围产期结局有关,包括更高的妊娠年龄和出生体重.
- 这些发现表明,显著的Hb下降可能反映出有利的血体积膨胀.
相关概念视频
Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Meiosis vs. Mitosis
54.8K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
54.8K
Multiple Allele Traits
34.1K
The Concept of Multiple Allelism
34.1K


