在之前接受过多次吸入器三重治疗的COPD患者中,extrafine单次吸入器三重治疗的有效性:TRIWIN研究
Paschalis Steiropoulos1, Niki Georgatou2, George Krommidas3
1Department of Pulmonology, Medical School, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Therapeutic advances in respiratory disease
|July 25, 2024
概括
在TRIWIN研究中发现,额外精细单次吸入器三重疗法 (efSITT) 显著改善了COPD评估测试得分,肺功能和坚持,同时减少了先前在多次吸入器三重疗法 (MITT) 上的患者的救援药物使用. 这种现实世界的证据支持efSITT.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 在受控试验中,包含贝克罗梅他松二 propionate/formoterol fumarate/glycopyrronium 87/5/9 μg的extrafine单次吸入器三重疗法 (efSITT) 对慢性慢性病有效.
- 在以前接受多次吸入器三重疗法 (MITT) 治疗的患者中,efSITT的实际有效性需要进一步调查.
研究的目的:
- 评估efsitt在希腊的实际有效性.
- 评估从MITT过渡到efSITT的COPD患者的健康状况,肺功能和药物坚持的改善.
主要方法:
- 一项前性,多中心,观察性,非干预性研究 (TRIWIN) 持续了24周.
- 475名在MITT治疗的有症状的COPD患者进行了COPD评估测试 (CAT) 评分,肺功能,救援药物的使用和坚持等方面的评估.
- 在基线,3个月和6个月收集的数据.
主要成果:
- 平均CAT得分显著下降 (21.4至15.1,p<0.001),其中79.8%的人取得了临床重要改善.
- 强迫呼气体积在1s (%预计) 中. 和强迫的生命能力 (%预计). 显著增加 (p<0.001).
- 吸入器坚持改善 (吸入器坚持测试得分从42.5增加到46.3,p<0.001),救援药物的使用减少 (16.2%到7.4%,p<0.001).
结论:
- efSITT有效改善之前接受MITT的COPD患者的健康状况,肺功能和坚持.
- 该研究提供了现实世界的证据,支持在希腊这个患者群体中使用efSITT.
- efSITT为需要三重治疗COPD治疗的患者提供了可行的替代方案.
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