接受丸激素治疗的跨性别男性的子宫变化
Eliane Dias da Silva1,2,3, Raquel Camara Riveri4, Poli Mara Spritzer1,2,3,5
1Postgraduate Program in Medical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), 90035-003 Porto Alegre, RS, Brazil.
European journal of endocrinology
|July 25, 2024
概括
用丸激素进行性别肯定激素治疗 (GAHT) 通常会导致跨性别男性的子宫内膜缩. 这项研究发现,经过大约5年的GAHT后,丸激素治疗似乎对经历了 amenorrhea 的跨性别男性是安全的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 跨性别者健康 跨性别者健康
- 在瘤学瘤学.
背景情况:
- 宫内出血可以发生在跨性别男性尽管性别肯定激素治疗 (GAHT).
- 了解子宫内膜和子宫肌膜的变化对于管理症状和确保安全至关重要.
研究的目的:
- 评估丸激素治疗中的跨性别男性子宫内膜和子宫肌膜中的组织学特征和受体表达 (ER,PR,AR).
- 将这些发现与临床和荷尔蒙数据相关联.
主要方法:
- 对34名接受性别确认手术的跨性别男性进行了回顾性横截面研究.
- 对临床,社会人口统计,实验室和解剖病理学数据的分析.
- 雌激素 (ER),孕激素 (PR) 和雄激素受体 (AR) 的免疫组织化学评估.
主要成果:
- 在平均5.36年的GAHT后,61.8%的参与者体内膜是缩的.
- 子宫内膜上皮细胞显示ER (90%) 和PR (80%) 的高表达,AR表达较低 (30%).
- 肌子膜表现出高的PR (90%) 和ER (70%) 表达,其中AR表达最高的是 (65%) 在这个层.
结论:
- 基于的GAHT会在大多数跨性别男性中诱导子宫内膜缩.
- 子宫内膜中有限的雄激素受体表达表明对的特定反应.
- 大约5年的丸激素治疗对于变性男性实现异常流血似乎是安全的.
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