在心理药物临床试验中包括种族:系统性审查
Marcus E Hughes1,2, Albert Garcia-Romeu3
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
EClinicalMedicine
|July 25, 2024
概括
在迷幻疗法研究中的种族和民族多样性仍然有限,白人参与者过度代表. 虽然最近的研究显示,包容性略有改善,但在迷幻研究中公平代表性需要取得重大进展.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在临床迷幻药研究中,有限的种族多样性是一个持续的担忧.
- 预计将对迷幻疗法的监管批准,需要对不同人群的数据.
- 自2018年以来,在迷幻研究中缺乏对种族和民族包容率的系统报告.
研究的目的:
- 系统地审查和报告心理辅助治疗研究中的民族种族纳入率.
- 为了比较2017年12月31日之前和之后的包容率,评估多样性的趋势.
- 评估迷幻研究研究的质量,并比较随着时间的推移的质量评级.
主要方法:
- 对1994年1月1日至2024年5月24日期间发表的研究进行了Pubmed/MEDLINE,EMBASE和Web of Science的系统审查.
- 研究被选出与精神病或物质使用障碍的迷幻疗法的相关性.
- 计算了民族种族群体的包容率,并使用五分尺度评估研究质量.
主要成果:
- 在787项选研究中,包括39项 (16项在2018年之前,23项在之后).
- 在2017年以后发表的研究中,85.6%的参与者是非西班牙裔白人;在美国的研究中,这一比例下降.
- 虽然2017年后少数民族人口的纳入增加了,特别是在美国的研究中,白人参与者仍然占多数.
结论:
- 在迷幻疗法研究中,种族少数群体的代表性仍然不足.
- 最近的研究表明,在更大的多样性方面取得了一些进展,特别是在美国的研究中.
- 进一步的努力至关重要,以确保心理治疗对普通人群安全有效.
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