饮食中摄入量与之间的关联:来自NHANES 2013-2018和孟德尔随机化研究的研究结果
Shicun Huang1, Ya Gao2, Yingqi Chen3
1Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, China.
Frontiers in nutrition
|July 25, 2024
概括
饮食中摄入量在5.0-11.0毫克/天之间与风险降低有关. 门德尔随机化 (MR) 分析支持和之间的因果关系,突出其神经保护潜力.
科学领域:
- 营养神经科学 营养神经科学
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 饮食中和之间的关系尚未得到充分证实.
- 在神经功能中起着至关重要的作用.
- 调查食对的影响对于公众健康至关重要.
研究的目的:
- 为了检查饮食中摄入量与之间的关联.
- 使用孟德尔随机化 (MR) 探索潜在的因果关系.
主要方法:
- 对NHANES数据 (2013-2018) 的横截面分析.
- 使用受限立方线和物流回归模型.
- 使用IVW方法采用2个样本的门德尔随机化 (MR).
主要成果:
- 一个L形曲线表明摄入量与风险之间存在非线性关系.
- 最佳摄入量 (5.0-11.0毫克/天) 与的几率较低有关 (OR=0.49).
- 核磁共振分析显示,摄入量与之间存在基因预测的逆相关性 (OR=1.06).
结论:
- 饮食中摄入量为5.0-11.0毫克/天与风险最低相关.
- 核磁共振的发现表明和之间存在因果关系.
- 充足的摄入量可能是预防的保护因素.
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