在何种流速下,大动脉梯度变得严重升高? 关于大动脉膜区域切断线路的指导方针建议的影响
Ayesha Salahuddin1, Wilbert S Aronow2, Daniel M Spevack1,2
1Department of Medicine, Cardiology Division, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.
Archives of medical science : AMS
|July 25, 2024
概括
该研究发现,单独的大动脉膜面积 (AVA) 不总是表明严重的大动脉狭窄 (AS). 平均大动脉梯度 (mAVG) 超过40mm Hg取决于跨膜流量,特别是在中度至重度的AS.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 严重的大动脉狭窄 (AS) 通常由大动脉面积 (AVA) <1.0 cm2和大动脉平均梯度 (mAVG) >40 mm Hg定义.
- 然而,许多AVA<1.0cm2的患者不符合mAVG标准,造成诊断模两可.
研究的目的:
- 为了确定特定的大动脉面积 (AVA) 值,在这个值下,大动脉的平均梯度 (mAVG) 倾向于在不同的跨膜流速中超过40 mm Hg.
- 为了澄清严重AS的诊断标准,在边界AVA和可变流量的情况下.
主要方法:
- 对200名原生门AS和AVA<1.0厘米2的患者的回顾性心声学数据的分析.
- 线性回归分析与mAVG相关,按AVA严重程度分层 (临界,严重,中度严重).
主要成果:
- 对于mAVG>40 mm Hg所需的MSF速率因AVA显著不同:120毫升/秒 (临界AVA<0.6厘米),183毫升/秒 (严重AVA0.6-0.79厘米) 和257毫升/秒 (中度严重AVA0.8-0.99厘米).
- 患者中度严重的AVA (0.8-0.99厘米2) 很少超过40mm Hg mAVG (8%),即使流量正常 (>200毫升/秒).
- 相反,严重的AVA (0.6-0.79cm2) 经常显示mAVG> 40mm Hg (75%) 与正常流量,和关键的AVA经常 (44%) 即使流量减少.
结论:
- 大动脉面积为0.8-0.9厘米2很少导致mAVG>40毫米克,无论正常的跨膜流速如何.
- 目前的指导方针可能无法充分将这些病例归类为严重的AS,强调需要精细的诊断标准.
- 跨膜流量是解释AS严重程度的mAVG的一个关键因素,特别是在边界AVA病例中.
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