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在怀孕期间使用真实世界的数据建立铜和的离散参考间隔和下一代参考间隔

Lihua Guan¹, Chaochao Ma^1,2, Liling Lin¹

¹Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, China.

|July 25, 2024

概括

这项研究确定了怀孕期间铜和的新参考间隔. 妊娠年龄对这些必不可少的微量元素产生重大影响,因此需要为孕妇更新临床指南.

科学领域:

生物化学生物化学
临床化学临床化学
微量元素的新陈代谢

背景情况:

铜和是健康怀孕和胎儿发育的重要微量元素.
对于这些元素在孕妇群体中的特定参考间隔 (RIs) 存在有限的研究.
建立准确的RI对于监测母亲和胎儿福祉至关重要.

研究的目的:

通过使用现实世界的数据,对孕妇的铜和建立离散和下一代参考间隔 (RIs).
分析妊娠年龄,孕妇年龄和孕妇对铜和水平在怀孕期间的影响.
提供更新的RI,更好地反映这些微量元素在整个孕期的动态变化.

主要方法:

追溯收集了710名健康孕妇和300名非孕妇对照组的数据.
怀孕和非怀孕群体之间的铜和水平的比较.
多变量回归分析以确定影响铜和水平的因素.
建立离散的RI (非参数) 和下一代RI (GAMLSS模型).

主要成果:

与非孕妇对照人群相比,孕妇的铜含量明显高 (p<0.001).
与非孕妇对照人群相比,孕妇的含量明显较低 (p<0.001).
铜和的含量在三个月内均表现出显著的变化,并受到妊娠年龄的强烈影响,而母亲的年龄表现出较弱的影响.

结论:

怀孕年龄是怀孕期间铜和水平的关键决定因素.
下一代RI有效地可视化趋势和微妙的变化,提供比离散RI更细致的视图.
这些发现支持在孕妇中对铜和进行持续,详细的RI的考虑,以改善临床监测.

关键词:

离散的参考区间是一个离散的参考区间.下一代参考区间的下一代参考区间.孕妇孕妇孕妇孕妇可以在中找到.铜铜铜铜的铜.

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