瘤微环境 (第一部分):外围神经癌症小鼠模型中的组织完整性
Ahmad Maqboul1,2, Bakheet Elsadek2
1Department of Anesthesiology and Operative Intensive Care Medicine, Charité-School of Medicine Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Heliyon
|July 25, 2024
概括
恶性瘤严重降低了坐骨神经中的细胞间粘附分子1 (ICAM-1). 髓蛋白零 (MPZ) 最初表现出防御反应,然后下降,突出显示癌症引起的神经损伤.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 细胞间粘附分子1 (ICAM-1) 和髓蛋白零 (MPZ) 对于神经组织的完整性至关重要.
- 外围神经损伤和神经元完整性的损失是恶性瘤的重要并发症.
研究的目的:
- 研究ICAM-1和MPZ在恶性坐骨神经组织中的表达.
- 了解ICAM-1和MPZ在癌症进展期间保护神经组织中的作用.
主要方法:
- 建立使用AT-1形瘤细胞的老鼠坐骨神经癌症模型.
- 在注射后7,14,21天采集和组织学检查坐骨神经组织.
- 针对ICAM-1和MPZ进行免疫组织化学染色,然后进行激光扫描显微镜.
主要成果:
- 在已建立的癌症模型中确认了瘤生长.
- 与对照人群相比,ICAM-1表达显著下降,与形细胞生长成比例.
- 在大幅下降之前,MPZ表现出最初的防御模式,表明神经受损.
结论:
- 恶性瘤对外围神经造成严重损伤,导致轴突损伤和神经元完整性丧失.
- ICAM-1和MPZ在保护神经组织免受癌症透和损伤方面发挥着至关重要的作用.
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