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现在是时候更认真地对待结肠直肠癌患者的HPV感染了

Mahsa Javadi^1,2, Shahram Jalilian^1,2, Malek Kanani³

¹Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Frontiers in medicine

|July 25, 2024

概括

在结直肠癌 (CRC) 患者中检测到人类乳头瘤病毒 (HPV) DNA,这表明HPV感染和CRC发展之间存在联系. 在尿液和血清外体中检测HPV显示了非侵入性癌症查的潜力.

科学领域:

在瘤学瘤学.
病毒学病毒学
分子生物学分子生物学

背景情况:

病毒感染,特别是人类乳头瘤病毒 (HPV) 与结直肠癌 (CRC) 之间的关联尚未完全理解.
在一些CRC活检中发现了致癌性高风险HPV (hr-HPV) 类型,需要进一步调查.

研究的目的:

在结直肠癌组织和尿液样本中调查HPVDNA的存在和基因定型.
在CRC患者和健康志愿者的血清外体中检测HPV16 E6/E7蛋白质.

主要方法:

对40例确诊的CRC腺癌病例进行横截面研究.
在新鲜的结直肠组织和尿液样本中检测HPV的HPVDNA杂交.
对HPV16 E6/E7型蛋白质的血清外体样本的西部斑分析.

主要成果:

在26/40名CRC患者中发现了HPVDNA,显著增加了患CRC的几率 (OR=7.4,p<0.001).
在HPV阳性CRC患者的14/26份尿样中检测到HPVDNA (p=0.013).
高风险HPV16是瘤 (24/40) 和尿液 (12/40) 样本中占主导地位的基因型. 在一个血清外体样本中检测到HPV16 E6/E7coproteins.

结论:

在CRC尿样中检测高风险HPVDNA有助于开发非侵入性查工具.
血清外体体中HPV16 E6/E7型蛋白的存在表明了对非侵入性诊断的潜力.
这些发现强调了HPV在CRC发展中的潜在作用,并倡导HPV疫苗接种计划.

关键词:

E6 蛋白质是一种E6蛋白质.E7 蛋白质是E7的蛋白质.人类乳头瘤病毒的人类乳头瘤病毒结肠直肠癌是什么意思外基因组是外基因组中的一个.尿液尿液尿液

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