Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Partial repair versus superior capsular reconstruction: comparable mid-term outcomes in non-pseudoparalytic massive irreparable rotator cuff tears.

BMC musculoskeletal disorders·2026
Same author

Integrated molecular and histological profiling of preeclampsia suggests angiogenic dysregulation associated with maternal and fetal outcomes.

Scientific reports·2026
Same author

Comparison of Endoscopic Plantar Fascia Release With and Without Calcaneal Spur Excision for Recalcitrant Plantar Fasciitis.

Foot & ankle orthopaedics·2026
Same author

Measurement of Proximal Humeral Cortical Bone Thickness to Predict Intraoperative Anchor Stability in Arthroscopic Rotator Cuff Repair: A Retrospective Case-Control Study of a Reliable Radiographic Marker for Surgical Planning.

Orthopaedic journal of sports medicine·2026
Same author

There Is No Clinical and Radiological Difference between Suspensory and Cortical Button Fixation at the Treatment of Medial Meniscus Posterior Root Tear.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2026
Same author

Suture tape-based SCR in massive rotator cuff tear repair provides comparable functional outcomes to biceps tendon-based SCR with a lower re-tear rate.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026

相关实验视频

Updated: Jun 19, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.2K

卫星肌细胞和介质干细胞注射在老鼠中减少旋转带撕裂后的脂肪退化.

Tahir Koray Yozgatli1, Elif Gelenli Dolanbay2, Tunca Cingoz1

  • 1Department of Orthopedic Surgery Acibadem University Faculty of Medicine Istanbul Turkey.

Journal of experimental orthopaedics
|July 25, 2024
PubMed
概括

手术修复与卫星肌细胞 (SM) 和介质干细胞 (MSC) 注射相结合,有效地治疗了老鼠的慢性旋转手套撕裂. 这种方法改善了肌肉质量,减少了脂肪退化,促进了更好的肌愈合和肌肉再生.

关键词:
脂肪退化 脂肪退化旋转器袖子的旋转器袖子干细胞疗法是一种干细胞疗法.手术修复手术修复的时间.

更多相关视频

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo
06:37

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo

Published on: September 18, 2019

14.8K
Isolation, Culture, and Transplantation of Muscle Satellite Cells
10:25

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Published on: April 8, 2014

41.5K

相关实验视频

Last Updated: Jun 19, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.2K
Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo
06:37

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo

Published on: September 18, 2019

14.8K
Isolation, Culture, and Transplantation of Muscle Satellite Cells
10:25

Isolation, Culture, and Transplantation of Muscle Satellite Cells

Published on: April 8, 2014

41.5K

科学领域:

  • 整形外科 整形外科 整形外科
  • 再生医学是一种再生医学.
  • 干细胞疗法是一种干细胞疗法.

背景情况:

  • 旋转手套撕裂往往导致脂肪退化,仅仅通过手术修复无法逆转.
  • 延迟治疗加剧了旋转手套撕裂中的脂肪退化.
  • 由于持续的脂肪退化,当前的手术方法可能无法完全恢复旋转手腕撕裂后的功能.

研究的目的:

  • 评估卫星肌细胞 (SM) 和介质干细胞 (MSC) 的局部注射在刺激肌形成和减少脂肪形成的有效性,在慢性旋转手套撕裂的老鼠模型中.
  • 为了确定结合干细胞治疗和手术修复是否可以逆转与旋转手套撕裂相关的脂肪退化.

主要方法:

  • 在24只威斯塔尔白色老鼠中创建了一个标准化的旋转手套撕裂模型.
  • 动物被分为两组:手术修复加SM和MSC注射 (n=12) 和仅手术修复 (n=12).
  • 在初始手术后的8,9,10周内注射,并随访至第14周.

主要成果:

  • 与仅进行修复和对照组相比,接受SM和MSC注射手术修复的组显示出明显更大的上肌肉质量.
  • 修复+SM和MSC组的脂肪组织比重明显低于仅修复和对照组.
  • 组织学分析显示,修复+SM和MSC组的肌肉和肌组织有所改善.

结论:

  • 手术修复与SM和MSC注射相结合,是慢性旋转手套撕裂的有希望的治疗方法.
  • 这种综合方法有效地改善脂肪退化,增强肌愈合,并刺激鼠标模型中的肌体发生.
  • 基于干细胞的治疗提供了一种潜在的策略,可以逆转与旋转手套撕裂相关的退行性变化.