肺结核与气管支气管结核的风险因素:倾向性得分匹配分析
Yinping Feng1, Jing Guo1, Shuirong Luo1
1Department of Tuberculosis, Lishui Hospital of traditional Chinese Medicine Affiliated to Zhejiang University of traditional Chinese Medicine, Lishui, 323000, People's Republic of China.
Infection and drug resistance
|July 25, 2024
概括
肺结核 (PTB) 与气管支气管结核 (TBTB) 与更长的疾病持续时间,糖尿病和肺腔有关. 早期查和干预对于PTB患者来说至关重要,以检测TBTB风险.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 医学诊断 医学诊断 医学诊断
背景情况:
- 肺结核 (PTB) 可以发展为气管支气管结核 (TBTB),导致诸如气管狭窄症和肺结核结核等并发症.
- 与PTB一起发展TBTB的特定风险因素尚不清楚,这阻碍了早期诊断.
- 这项研究调查了在PTB患者中与TBTB相关的风险因素.
研究的目的:
- 在被诊断为肺结核 (PTB) 的患者中,确定气管支气管结核病 (TBTB) 的特定危险因素.
- 为早期诊断和治疗TBTB提供见解.
- 改善结合PTB和TBTB患者的临床结果.
主要方法:
- 这是一项回顾性研究,包括在2021年1月至2023年10月期间住院的643名PTB患者.
- 根据支气管镜检查,患者被分为PTB和PTB与TBTB组.
- 倾向性得分匹配 (PSM) 和多变量逻辑回归被用来确定风险因素.
主要成果:
- 在643名PTB患者中,227名 (35.30%) 被诊断为TBTB.
- 在PSM之后,204对患者被匹配,没有显著的基线差异.
- 病程≥1个月 (OR=1.85),糖尿病 (OR=3.00) 和肺腔 (OR=3.46) 是TBTB的重要风险因素.
结论:
- 至少一个月的疾病持续时间,并发性糖尿病和肺腔的存在被确定为PTB患者TBTB的关键风险因素.
- 这些发现强调了加强TBTB查方案在有风险的PTB人群中的重要性.
- 建议采取早期检测和干预策略,以减轻与TBTB相关的并发症.
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