自然产品作为乳腺癌免疫治疗的有希望的调节剂
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Frontiers in immunology
|July 25, 2024
概括
天然化合物通过调节免疫反应,在乳腺癌免疫治疗中表现有前途. 它们增强抗瘤免疫力,抑制免疫抑制细胞,提供一种潜在的更安全的治疗选择.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌 (BC) 是女性全球领先的健康挑战.
- 目前的BC治疗包括手术,放射治疗,化疗,激素治疗和免疫治疗.
- 免疫疗法越来越多地用于个性化癌症护理,因为它的向方法和毒性比化疗更低.
研究的目的:
- 审查乳腺癌中的免疫反应途径.
- 解释自然化合物如何调节对乳腺癌的免疫反应.
- 探索天然产品在乳腺癌免疫治疗中的治疗潜力.
主要方法:
- 关于乳腺癌免疫反应途径的文献综述.
- 对自然化合物的免疫调节作用的研究分析.
- 对研究自然产品对免疫细胞和细胞因子的影响的研究进行审查.
主要成果:
- 自然化合物显著影响免疫细胞和细胞因子,促进免疫性癌症细胞死亡.
- 观察到巨细胞,CD+8 T细胞,自然杀手细胞和树突细胞的升级.
- 免疫抑制细胞 (Treg,MDSCs) 和因子 (TGF-β,IL-10) 的抑制已经证明.
- 发现天然化合物可以针对PD-L1.1.等免疫检查点.
结论:
- 自然产品为乳腺癌免疫治疗提供了一个有希望的途径.
- 这些化合物可以增强抗瘤免疫反应,克服免疫抑制.
- 对天然化合物的进一步研究可能会导致新的,毒性较低的乳腺癌治疗方法.
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