干皮肤和毒的活性成分的输送系统的进展
Dan Zhang1, Bingtao Zhai1, Jing Sun1
1State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi University of Chinese Medicine, Xi'an, 712046, People's Republic of China.
International journal of nanomedicine
|July 25, 2024
概括
干燥的皮和毒液 (TS/TV) 含有具有抗瘤功能的类. 针对性药物递送系统 (TDDS) 正在探索,以克服这些天然抗癌剂的局限性并增强其临床使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 在瘤学瘤学.
背景情况:
- 来自*Bufo*物种的干皮 (TS) 和毒 (TV) 是类的来源,它们因其抗瘤活性而闻名.
- 自2005年以来,来自TS/TV的Cinobufacini制剂已被批准作为辅助癌症疗法.
- 布法利诺利德通过诱导亡和通过多个信号通路抑制癌细胞增殖和转移来显示抗癌作用.
研究的目的:
- 对TS/TV及其活性成分进行针对性药物递送系统 (TDDS) 的审查.
- 解决与TS/TV相关的挑战,包括毒性,溶解性差,生物可用性低和快速清除.
- 为推进基于TS/TV的抗癌疗法的临床开发和应用提供参考.
主要方法:
- 审查有关TS/TV及其活性成分的现有文献.
- 分析不同类型的TDDS,包括被动,主动和刺激响应系统.
- 评估TDDS如何改善bufalenolides的药理动力学和药理动力学概况.
主要成果:
- TDDS提供了一个有前途的策略,以提高bufalenolides的生物可用性和瘤向.
- 被动,活跃和对刺激有反应的TDDS可以减轻固有的毒性,并提高TS/TV组件的有效性.
- 开发有效的TDDS对于克服当前基于TS/TV的癌症治疗的局限性至关重要.
结论:
- 针对性的药物输送系统对于优化TS/TV. bufalenolides的治疗潜力至关重要.
- 对先进的TDDS设计的进一步研究可以导致更有效,更安全的癌症疗法.
- 本综述强调了TDDS在弥合天然产品发现和瘤学临床应用之间的差距方面的重要性.
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