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Updated: Jun 19, 2025

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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模拟指导工程使得Selinadiene合成酶的功能转换成为向氧化转化的功能转换

Prabhakar L Srivastava1, Sam T Johns2, Angus Voice2

  • 1School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K.

ACS catalysis
|July 25, 2024
PubMed
概括

研究人员设计了一种甲合成酶,以产生一种特定的氧化甲. 这种以模拟为指导的方法实现了48%的产量,证明了创造复杂分子的潜力.

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