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同时刺激CD28/CD40信号分子增强了CAR-T细胞的疗效和干细胞性

Wannakorn Khopanlert1,2,3, Pongsakorn Choochuen2,4, Kajornkiat Maneechai1,2,3

  • 1Stem Cell Laboratory, Hematology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Molecular therapy. Oncology
|July 25, 2024
PubMed
概括

用双重共刺激分子 (CD28和CD40) 改造的CD19 CAR-T细胞表现出增强的持久性和强大的抗瘤活性,对抗B细胞恶性瘤. 这种修改改善了T细胞的增殖,记忆和长期疗效 in vivo.

关键词:
在CAR-T细胞中.CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19 CD19CD28/CD40 CD28/CD40 CD28/CD40 CD28/CD40 CD40 CD28/CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD28 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD4 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD5 CD4 CD5 CD7 CD4 CD4 CD4 CD4 CD5 CD7 CD7 CD7 CD7 CD7 CD8 CD7 CD8 CD8 CD7 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD9 CD8 CD8 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37 CD37MT: 定期发行 定期发行共同刺激的领域.

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