欧米德内帕格异乙烯0.002%与拉坦诺普罗斯特0.005%在开放角度的玻璃眼/眼睛高血压:随机的第三阶段PEONY试验
Tsing Hong Wang1, Tin Aung2,3,4, Da-Wen Lu5
1Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Clinical ophthalmology (Auckland, N.Z.)
|July 25, 2024
概括
奥米德内帕格异烯 (OMDI) 在亚洲患者中有效降低眼内压力 (IOP),这些患者患有开角玻璃眼 (OAG) 或眼睛高血压 (OHT). 这项研究发现,OMDI在降低IOP方面与拉坦诺普罗斯特无差,证明了其安全性和有效性.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验 临床试验
- 药理学 药理学是指药理学的学科.
背景情况:
- 视角大光眼 (OAG) 和眼高血压 (OHT) 是全球不可逆转失明的主要原因.
- 降低有效的眼内压力 (IOP) 是管理OAG/OHT的主要目标.
- 亚洲人群可能对青光眼药物有独特的反应.
研究的目的:
- 为了比较omidenepag isopropyl (OMDI) 0.002%与latanoprost 0.005%每天一次的疗效和安全性.
- 为了评估亚洲被诊断患有OAG/OHT的受试者的内血压降低.
主要方法:
- 一个第三阶段,随机,观察者蒙面,主动控制,跨国试验.
- 每组有185名OAG/OHT和基线IOP在22-34mmHg之间的人被随机分为1:1给OMDI或拉坦诺普罗斯特.
- 在基线和后续访问中,IOP在上午9点,下午1点和下午5点被测量到3个月.
主要成果:
- 从基线到3个月的平均日间IOP降低为OMDI的7.1 mmHg (28.8%) 和拉坦诺普罗斯特的7.8 mmHg (31.3%),表明非劣势性 (p=0.0366).
- 在所有测量时间点上,IOP降低的非劣质性标准都得到了满足.
- 对OMDI的不良事件发生率高于 (40.0%) 比拉坦诺普罗斯特 (29.7%),结膜性高血症在OMDI中更频繁 (11.9%对5.4%).
结论:
- 奥米德内帕格异 (OMDI) 证明在亚洲受试者中安全有效地降低了内脏压力,这些受试者患有OAG/OHT.
- 在降低平均日间内血压和每时点内血压方面,OMDI与拉坦诺普罗斯特无差.
- 安全性概况是可以接受的,大多数不良事件是轻微的.
相关概念视频
Open Angle Glaucoma: Treatment
422
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
422
Angle Closure Glaucoma: Treatment
468
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
468
Glaucoma: Overview
534
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
534
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
165
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
165


