患有先天性长QT综合征的患者进行剧烈运动:前性观察性多国LIVE- LQTS研究的结果
Rachel Lampert1, Sharlene Day2,3, Barbara Ainsworth4,5
1Yale School of Medicine, New Haven, CT (R.L., M.B., C. Barth, J.D., F.L, L.S.).
Circulation
|July 25, 2024
概括
在先天长QT综合征 (LQTS) 患者中,强度运动没有增加心脏事件的风险. 强烈运动者和不强烈运动者之间的事件率相似,为患者和医生的体育参与讨论提供了信息.
科学领域:
- 心脏病学
- 遗传学
- 运动生理学
背景情况:
- 遗传性长QT综合征 (LQTS) 是一种影响心律的遗传性疾病.
- 在接受治疗的LQTS患者中,强度运动对心室节律失常的影响尚不清楚.
研究的目的:
- 调查强度运动是否会增加被诊断和治疗LQTS的患者心室失律的风险.
- 在大型LQTS队列中,比较活跃和非活跃运动者的心脏事件率.
主要方法:
- 这项LIVE- LQTS研究在5个国家招募了1413名LQTS患者 (8-60岁).
- 参与者报告了3年的身体活动和临床事件;强度运动被定义为≥6MET每年60小时.
- 一个复合的终点是突然死亡,心脏骤停,除器治疗的心室节律失常和昏迷.
主要成果:
- 52%的参与者进行了剧烈的运动;37人经历了3年的复合终点.
- 发生率相似:有力的运动者为2. 6%,非有力的运动者为2. 7%.
- 剧烈运动者的调整后危险比为1. 17 (90% CI,0. 67-2. 04),没有证明非劣势性.
结论:
- 在接受治疗的患者中,与LQTS相关的心脏事件在炼者和不炼者之间较低且相似.
- 广泛的置信区间表明需要进一步研究,但目前的数据支持共享决策.
- 这些发现为有关LQTS个体运动和竞技运动的讨论提供了信息.
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