在的早期阶段,额头皮肤微生物组的表征
M Maître1, E Gravier1, A Simcic-Mori1
1Pierre Fabre Dermo-Cosmétique and Personal Care, Research & Development, Toulouse, France.
概括
的早期阶段显示皮肤微生物群的不平衡,细菌的丰富性和多样性发生变化. 针对面部皮肤中的这种失生症可以防止病变的发展.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 基因组学就是基因组学.
背景情况:
- 与皮肤微生物群不平衡有关.
- 早期的发作及其微生物变化尚未得到充分了解.
研究的目的:
- 在亚临床阶段对皮肤微生物群的特征.
- 为了比较成人和青少年的微生物组成,有和没有.
主要方法:
- 在和非患者中比较非损伤的额头皮肤微生物群.
- 使用16SrRNA,tuf和ITS1基因的高通量测序.
- 分析了细菌和真菌的相对丰度,α-多样性和β-多样性.
主要成果:
- 患者的Cutibacterium数量较高,而Corynebacterium/Streptococcus数量较低.
- 在细菌多样性 (丰富性,均性,丰富性,遗传学距离) 中观察到显著差异.
- Staphylococcus epidermidis在患者中占主导地位,而S. capitis在非患者中占主导地位;真菌成分保持相似.
结论:
- 在额头皮肤上早期的亚临床中显而易见.
- 细菌种群的丰富性,丰富性和均性在患者中减少.
- 早期重新平衡面部皮肤微生物群可能会防止病变的发展.
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