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Updated: Jun 19, 2025

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
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单克隆抗体的临床药理动力学的抗体间变异性,使用基于人群生理学的药理动力学建模来表征

Mokshada Kumar1, Sravani Lanke1, Alka Yadav1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY 14214-8033, USA.

Antibodies (Basel, Switzerland)
|July 25, 2024
PubMed
概括

一个新的基于人群生理学的药理动力学 (popPBPK) 模型预测单克隆抗体 (mAb) 临床PK. 这种工具有助于预测mAb的处置,并优化新抗体疗法的首次人体剂量.

关键词:
在PBPK模型中,抗体是一种抗体.临床药理学临床药理学药物动力学 药物动力学

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