长期接触电子烟和传统香烟会改变小鼠的乳房和结肠周转率,免疫功能和屏障完整性
Madjid Djouina1, Anaïs Ollivier2, Christophe Waxin1
1Univ. Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France.
Journal of xenobiotics
|July 25, 2024
概括
电子烟气溶 (e-cig) 和香烟烟雾 (CS) 都对肠道有害. 电子烟暴露会改变肠道的增殖,炎症和屏障功能,造成严重的肠道健康风险.
科学领域:
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
- 微生物组研究的研究.
背景情况:
- 香烟烟雾与各种肠道疾病有关.
- 电子烟气溶 (e-cig) 对消化系统健康的影响在很大程度上仍未被描述.
研究的目的:
- 为了比较电子烟和CS暴露对小鼠大肠和大肠的影响.
- 调查肠道增殖,炎症,屏障功能和微生物群的潜在变化.
主要方法:
- 通过鼻子吸入,老鼠长期暴露在电子烟 (18或30 W) 或3R4F CS中6个月.
- 评估的是结肠细胞增殖,蛋白质水平 (环素D1,ZO-1,奥克卢丁),髓氧化酶活性,基因表达 (细胞因子,T细胞因子) 和肠道微生物群组成 (16S测序).
主要成果:
- 电子烟暴露减少了结肠细胞的增殖,并改变了大肠和大肠中的cyclin D1水平.
- 电子烟和CS都降低了叶髓氧化酶活性,并破坏了结肠细胞因子和T细胞基因表达.
- 电子烟和CS暴露分别降低了骨和结肠中的ZO-1和奥克卢丁蛋白水平,这表明屏障被破坏.
- 16S测序揭示了轻度,暴露特异性肠道失调.
结论:
- 电子烟暴露会导致肠道增殖,炎症和大肠和大肠两侧的屏障完整性发生显著变化.
- 电子烟对肠道健康的危害与传统香烟烟雾相美.
- 需要进一步的研究来了解电子烟使用对消化系统健康的长期影响.
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