冠状动脉疾病患者手握强度与死亡率之间的关联:元分析
Meiling Xiao1, Yu Lu2, Hongqiu Li1
1Department of Rehabilitation, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Clinical cardiology
|July 25, 2024
概括
在冠状动脉疾病 (CAD) 患者中,手握强度 (HGS) 较弱表明死亡风险较高. 这种风险在患有CAD的老年人中尤为明显,突出显示HGS是关键的健康指标.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 老年病的医生 老年病的医生
背景情况:
- 肌肉力量是影响一般人群心血管疾病风险的已知因素.
- 手握强度 (HGS) 是总体肌肉强度的一个易于测量的指标.
- 在已确诊的冠状动脉疾病 (CAD) 患者中,HGS和死亡率之间的关系需要进一步阐明.
研究的目的:
- 系统地审查和元分析观察性研究.
- 评估低握力 (HGS) 与被诊断为冠状动脉疾病 (CAD) 的患者的死亡风险之间的关联.
主要方法:
- 在多个主要科学数据库 (PubMed,Embase,Web of Science,Cochrane图书馆,万芳,CNKI) 进行了广泛的文献搜索.
- 包括具有纵向随访数据的观察性研究.
- 采用随机效应模型来综合发现,并考虑研究异质性.
主要成果:
- 分析了包括10,543名CAD患者在内的8项研究.
- 平均随访时间为20.4个月,发现1327人 (12.6%) 死亡.
- 低基线HGS与所有原因死亡风险增加显著相关 (RR: 1.95,95%CI: 1.50-2.55).
- 与整体队列 (RR: 1.60) 相比,在老年CAD患者中观察到更强的关联 (RR: 3.01).
结论:
- 基线手握强度是冠状动脉疾病患者死亡率的重要预测因素.
- 患有CAD和低HGS的老年患者面临着特别高的死亡风险.
- 在CAD患者的管理中,HGS作为一个有价值的预后标志物.
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