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Updated: Jun 19, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Published on: October 4, 2019

恩多博林A-L,来自Aspergillus undulatus的Ophiobolin类型的特类

Yuyi Zheng¹, Qin Li¹, Minglang Gu¹

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

Journal of natural products

|July 25, 2024

概括

研究人员发现了来自Aspergillus undulatus的十二种新的ophiobolin类型的sesterterpenoid. 一种化合物表现出显著的免疫抑制活性,为新药开发提供了潜力.

科学领域:

自然产品化学化学
化学生物学化学生物学
菌类学菌类学是指菌类学.

背景情况:

奥菲奥博林是一种具有多样化的生物活动的sesterterpenoid类.
亚斯伯吉洛菌种是已知的生物活性二次代谢产物的来源.

研究的目的:

从Aspergillus undulatus中分离和描述新型的ophiobolin类型的塞斯特特类物质.
评估分离化合物的免疫抑制潜力.

主要方法:

使用色谱技术分离和净化化合物.
通过光谱分析 (NMR,MS) 和X射线晶体学来阐明结构.
对ConA诱导的T淋巴细胞增殖的抑制活性的评估.

主要成果:

鉴定出了12种新的ophiobolin类型的sesterterpenoid,称为undobolins A-L (1-12),它们被命名为undobolins.
化合物1代表了一种罕见的20-nor-ophiobolin.
化合物2-6呈现出独特的C-2氧化模式.
恩多博林F (6) 显示T淋巴细胞增殖的强烈抑制 (IC50 = 2.3μM).

结论:

这项研究扩大了已知的ophiobolin sesterterpenoids的多样性.
恩多博林F显示出作为一种用于开发新型免疫抑制剂的化合物的前景.
阿斯伯吉路斯度是一种有价值的结构独特和生物活性天然产品来源.

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